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Tofacitinib (tasocitinib, CP-690550), Pfizer鈥檚 novel Janus Kinase 3 (JAK) inhibitor for the treatment of rheumatoid arthritis (RA), had an anticipated FDA PDUFA (Prescription Drug User Fee Act) date for, August 21, 2012.The FDA has just announced it has extended the review period of tofacitinib by three months. Interestingly, earlier in August, more data from The ORAL Start Phase III clinical trials were submitted by Pfizer for review, thus pushing the anticipated PDUFA date potentially into Q4.The safety profile more than the efficacy profile o dunk low f tofacitinib was brought into question, even during the May 2012 FDA advisory panel meeting.The oral JAK3 therapy is also in Phase III for other indications, such as psoriasis (oral) and ulcerative colitis (UC), and Phase II fo nike jordan r yeezys psoriatic arthritis, ankylosing spondylitis, psoriasis (topical), and Crohn鈥檚 disease.Tofacitinib targets the JAK pathway, thus disrupting the intracellular signal pathway which is used by cytokines to regulate immune r KARACHI:Noted educationist Abdul Wahab breathed his last on Tuesday at Karachi's Aga Khan University Hospital following a protracted illness.Wahab was 77. He had been hospitalised several times in the recent past. Wahab was associated with Karachi University (KU), the Institute of Business Administration (IBA) and Muhammad Ali Jinnah University (MAJU) over his distinguished career.Wahab, who served the nation without fearing anyone, was among the聽few successful VC's in the history of KU who made the changes on a bet adidas campus homme ter note. Wahab completed his master鈥檚 in business administration from the IBA and obtained another聽from Indiana in the United States of America. The deceased聽also had a doctorate degree from the University of British Columbia in Canada.Revelations: The man who denied admission to his own son launches bookThe fearless educationist serv ugg boots damen ed as the KU acting VC from July 6, 1994 to聽April 4, 199 stanley cup 5 and聽VC and from April 5, 1995 to November 9, 1996. He also served at the IBA聽as the
Tofacitinib (tasocitinib, CP-690550), Pfizer鈥檚 novel Janus Kinase 3 (JAK) inhibitor for the treatment of rheumatoid arthritis (RA), had an anticipated FDA PDUFA (Prescription Drug User Fee Act) date for, August 21, 2012.The FDA has just announced it has extended the review period of tofacitinib by three months. Interestingly, earlier in August, more data from The ORAL Start Phase III clinical trials were submitted by Pfizer for review, thus pushing the anticipated PDUFA date potentially into Q4.The safety profile more than the efficacy profile o dunk low f tofacitinib was brought into question, even during the May 2012 FDA advisory panel meeting.The oral JAK3 therapy is also in Phase III for other indications, such as psoriasis (oral) and ulcerative colitis (UC), and Phase II fo nike jordan r yeezys psoriatic arthritis, ankylosing spondylitis, psoriasis (topical), and Crohn鈥檚 disease.Tofacitinib targets the JAK pathway, thus disrupting the intracellular signal pathway which is used by cytokines to regulate immune r KARACHI:Noted educationist Abdul Wahab breathed his last on Tuesday at Karachi's Aga Khan University Hospital following a protracted illness.Wahab was 77. He had been hospitalised several times in the recent past. Wahab was associated with Karachi University (KU), the Institute of Business Administration (IBA) and Muhammad Ali Jinnah University (MAJU) over his distinguished career.Wahab, who served the nation without fearing anyone, was among the聽few successful VC's in the history of KU who made the changes on a bet adidas campus homme ter note. Wahab completed his master鈥檚 in business administration from the IBA and obtained another聽from Indiana in the United States of America. The deceased聽also had a doctorate degree from the University of British Columbia in Canada.Revelations: The man who denied admission to his own son launches bookThe fearless educationist serv ugg boots damen ed as the KU acting VC from July 6, 1994 to聽April 4, 199 stanley cup 5 and聽VC and from April 5, 1995 to November 9, 1996. He also served at the IBA聽as the